H1/H1 genotype influences symptom severity in corticobasal syndrome
Identifieur interne : 001C61 ( Main/Exploration ); précédent : 001C60; suivant : 001C62H1/H1 genotype influences symptom severity in corticobasal syndrome
Auteurs : Irene Litvan [États-Unis] ; Amanda Chism [États-Unis] ; Juan Litvan [États-Unis] ; Alex Cambon [États-Unis] ; Michael Hutton [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-04-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Age of Onset, ApoE, Apolipoprotein E4 (genetics), Case-Control Studies, Dystonia (complications), Dystonia (genetics), Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, H1/H1 genotype, Humans, Influence syndrome, Male, Mental Status Schedule, Middle Aged, Nervous system diseases, Psychomotor Disorders (complications), Psychomotor Disorders (genetics), Severity of Illness Index, Syndrome, corticobasal syndrome, tau Proteins (genetics).
- MESH :
- chemical , genetics : Apolipoprotein E4, tau Proteins.
- complications : Dystonia, Psychomotor Disorders.
- genetics : Dystonia, Psychomotor Disorders.
- Age of Onset, Case-Control Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Mental Status Schedule, Middle Aged, Severity of Illness Index, Syndrome.
Abstract
We evaluated 38 consecutive patients with corticobasal syndrome to determine if inheritance of the H1/H1 genotype influences age at onset and disease severity and if Apolipoprotein E e4 increases the risk of cognitive disturbances. Inheritance of the H1/H1 genotype was associated with severity of motor function, but did not affect age at onset or cognition. There was a trend toward shorter survival in the H1/H1 group, but this study was underpowered to test influence on survival, even though it served to estimate the sample size for future studies. ApoE inheritance did not influence cognition. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22804
Affiliations:
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BMB8‐106, 33 Avenue Louis Pasteur, Boston</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-04-30">2010-04-30</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="760">760</biblScope><biblScope unit="page" to="763">763</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DD96E4138383DB0F9529E2F55C54E502992F19A9</idno><idno type="DOI">10.1002/mds.22804</idno><idno type="ArticleID">MDS22804</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term><term>ApoE</term><term>Apolipoprotein E4 (genetics)</term><term>Case-Control Studies</term><term>Dystonia (complications)</term><term>Dystonia (genetics)</term><term>Female</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>H1/H1 genotype</term><term>Humans</term><term>Influence syndrome</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Psychomotor Disorders (complications)</term><term>Psychomotor Disorders (genetics)</term><term>Severity of Illness Index</term><term>Syndrome</term><term>corticobasal syndrome</term><term>tau Proteins (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoprotein E4</term><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dystonia</term><term>Psychomotor Disorders</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dystonia</term><term>Psychomotor Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term><term>Case-Control Studies</term><term>Female</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Génotype</term><term>Pathologie du système nerveux</term><term>Syndrome d'influence</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We evaluated 38 consecutive patients with corticobasal syndrome to determine if inheritance of the H1/H1 genotype influences age at onset and disease severity and if Apolipoprotein E e4 increases the risk of cognitive disturbances. Inheritance of the H1/H1 genotype was associated with severity of motor function, but did not affect age at onset or cognition. There was a trend toward shorter survival in the H1/H1 group, but this study was underpowered to test influence on survival, even though it served to estimate the sample size for future studies. ApoE inheritance did not influence cognition. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li><li>Kentucky</li><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Kentucky"><name sortKey="Litvan, Irene" sort="Litvan, Irene" uniqKey="Litvan I" first="Irene" last="Litvan">Irene Litvan</name></region><name sortKey="Cambon, Alex" sort="Cambon, Alex" uniqKey="Cambon A" first="Alex" last="Cambon">Alex Cambon</name><name sortKey="Chism, Amanda" sort="Chism, Amanda" uniqKey="Chism A" first="Amanda" last="Chism">Amanda Chism</name><name sortKey="Hutton, Michael" sort="Hutton, Michael" uniqKey="Hutton M" first="Michael" last="Hutton">Michael Hutton</name><name sortKey="Hutton, Michael" sort="Hutton, Michael" uniqKey="Hutton M" first="Michael" last="Hutton">Michael Hutton</name><name sortKey="Litvan, Juan" sort="Litvan, Juan" uniqKey="Litvan J" first="Juan" last="Litvan">Juan Litvan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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